Naoto Ishibashi Selected Research

3,7,11,15- tetramethyl- 2,4,6,10,14- hexadecapentaenoic acid

1/2018	Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid.
3/2016	Metabolome Analyses Uncovered a Novel Inhibitory Effect of Acyclic Retinoid on Aberrant Lipogenesis in a Mouse Diethylnitrosamine-Induced Hepatic Tumorigenesis Model.
1/2013	The effect of acyclic retinoid on the metabolomic profiles of hepatocytes and hepatocellular carcinoma cells.
1/2011	Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells.
8/2010	Chemopreventive anti-cancer agent acyclic retinoid suppresses allogeneic immune responses in rats.
1/2010	Acyclic retinoid inhibits angiogenesis by suppressing the MAPK pathway.
7/2007	Acyclic retinoid inhibits neointima formation through retinoic acid receptor beta-induced apoptosis.
5/2007	An antioxidant effect by acyclic retinoid suppresses liver tumor in mice.

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Naoto Ishibashi Research Topics

Disease

8	Hepatocellular Carcinoma (Hepatoma) 01/2018 - 01/2005
7	Neoplasms (Cancer) 09/2014 - 06/2004
2	Liver Neoplasms (Liver Cancer) 01/2018 - 05/2007
2	Carcinogenesis 03/2016 - 01/2005
2	Body Weight (Weight, Body) 09/2010 - 01/2005
1	Inflammation (Inflammations) 03/2016
1	Fatty Liver 01/2009
1	Neointima 07/2007
1	Adenoma (Adenomas) 06/2004
1	Carcinoma (Carcinomatosis) 06/2004

Drug/Important Bio-Agent (IBA)

8	3,7,11,15- tetramethyl- 2,4,6,10,14- hexadecapentaenoic acidIBA 01/2018 - 05/2007
5	(2E,4E,6E,10E)- 3,7,11,15- tetramethyl- 2,4,6,10,14- hexadecapentaenoic acidIBA 09/2010 - 06/2004
2	Diethylnitrosamine (N-Nitrosodiethylamine)IBA 03/2016 - 01/2011
2	RetinoidsIBA 01/2009 - 07/2007
2	Transforming Growth Factor alpha (TGF-alpha)IBA 01/2005 - 06/2004
1	Pharmaceutical PreparationsIBA 03/2016
1	LipidsIBA 03/2016
1	Glucose (Dextrose)FDA LinkGeneric 03/2016
1	Arachidonic Acid (Vitamin F)IBA 03/2016
1	COUP Transcription Factor IIIBA 03/2016
1	Linoleic Acid (Linoleate)IBA 03/2016
1	ErbB Receptors (EGF Receptor)IBA 01/2011
1	Caspase 3 (Caspase-3)IBA 01/2011
1	Sp1 Transcription FactorIBA 01/2011
1	TransglutaminasesIBA 01/2011
1	Vitamin A (Retinol)FDA LinkGeneric 09/2010
1	Bromodeoxyuridine (BrdU)IBA 09/2010
1	SolventsIBA 09/2010
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 09/2010
1	IronIBA 01/2009
1	retinoic acid receptor betaIBA 07/2007
1	Therapeutic UsesIBA 07/2007
1	AntioxidantsIBA 05/2007
1	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2007
1	Retinoic Acid Receptor alphaIBA 05/2007
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2005
1	Drinking WaterIBA 06/2004

Therapy/Procedure

1	Chemoprevention 03/2016
1	Therapeutics 09/2014
1	Aftercare (After-Treatment) 01/2013
1	Hepatectomy 09/2010